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Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor

✍ Scribed by Nancy E Buckley; Kathleen L McCoy; Éva Mezey; Tom Bonner; Anne Zimmer; Christian C Felder; Michelle Glass; Andreas Zimmer


Book ID
114012983
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
242 KB
Volume
396
Category
Article
ISSN
0014-2999

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Activation of Kupffer cells plays a central role in the pathogenesis of alcoholic liver disease. Because cannabinoid CB2 receptors (CB2) display potent anti-inflammatory properties, we investigated their role in the pathogenesis of alcoholic liver disease, focusing on the impact of CB2 on Kupffer ce