𝔖 Bobbio Scriptorium
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Immunological studies of β-adrenergic receptors

✍ Scribed by P. O. Couraud; B. Z. Lu; A. Schmutz; O. Durieu-Trautmann; C. Klutchko-Delavier; J. Hoebeke; A. D. Strosberg

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
411 KB
Volume
21
Category
Article
ISSN
0730-2312

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✦ Synopsis

Two types for antibodies have been raised against the beta-adrenergic receptor: either by injection of highly purified receptor from turkey erythrocytes or by injection of anticatecholamine ligand antibodies, and induction of anti-idiotypic antibodies. Our data illustrate the interactions of the beta-adrenergic receptor with these polyclonal antibodies. Preliminary results with monoclonal antibodies are also described. The redistribution of beta-receptors on intact cells is visualized by the use of fluorescent antibodies. Immunoprecipitation of radioiodinated receptor by the antireceptor antibodies yields a single major 60,000 MW component.

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