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Immunological studies of acetylcholine receptors

✍ Scribed by Lindstrom, Jon

Publisher
Wiley (John Wiley & Sons)
Year
1976
Tongue
English
Weight
699 KB
Volume
4
Category
Article
ISSN
0091-7419

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✦ Synopsis

Abstract

Immunochemical techniques for the study of acetylcholine receptors are described. Immunization of rabbits, rats, guinea pigs, and goats with acetylcholine receptor protein purified from Electrophorus electric organ tissue results in muscular weakness and death due to impaired neuromuscular transmission. Serum from immunized animals contains high concentrations of antibodies directed at receptors from the electric organ and low concentrations of antibodies directed at receptors from skeletal muscle. The detailed similarities between the disease of receptor‐immunized animals, β€œexperimental autoimmune myasthenia gravis” (EAMG), and myasthenia gravis are compared. Reactions of antisera from animal with EAMG with receptor from Electrophorus and Torpedo are studied. Antireceptor antibodies in these antisera are directed predominantly at determinants other than the acetylcholine‐binding site.

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