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Immunological detection of metastases from prostatic adenocarcinoma

✍ Scribed by Dr. John A. Heaney; Julia C. Lin; James J. Daly; George R. Prout JR.

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
377 KB
Volume
17
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

In six patients with known prostatic adenocarcinoma, extraprostatic (metastatic) tumor was suspected on radiographic or radionucleotide studies. When cytological examination of tissue obtained by needle aspiration or biopsy was nondiagnostic, radial gel immunodiffusion was used to identify the presence of prostatic acid phosphatase in the tissue. Four specimens demonstrated prostate‐specific acid phosphatase activity, permitting the diagnosis of metastatic prostatic adenocarcinoma. The technique is simple and highly specific.

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Genetic alterations within diseased prostate tissue were analysed by genomic DNA fingerprinting using a minisatellite probe (lambda 33.6), a simple repetitive oligonucleotide probe (GTG),, and an additional human multilocus probe (pV47-2). In prostatic adenocarcinoma, somatic mutations were detected