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Immunological control of cell cycle aberrations for the avoidance of oncogenesis: the case of tetraploidy

✍ Scribed by Senovilla, Laura; Galluzzi, Lorenzo; Castedo, Maria; Kroemer, Guido


Book ID
121197310
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
164 KB
Volume
1284
Category
Article
ISSN
0890-6564

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## Abstract The serine/threonine kinase PAK4 regulates cytoskeletal architecture, and controls cell proliferation and survival. In most adult tissues PAK4 is expressed at low levels, but overexpression of PAK4 is associated with uncontrolled proliferation, inappropriate cell survival, and oncogenic