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Immunological Challenges in Late-Onset Pompe Disease Treated with Enzyme Replacement Therapy

✍ Scribed by Trusha Patel; Suhrad Banugaria; Stephanie DeArmey; Joanne Mackey; Priya Kishnani


Book ID
116989613
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
54 KB
Volume
105
Category
Article
ISSN
1096-7192

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Enzyme replacement therapy induces T-cel
✍ Miklos Banati; Zsolt Hosszu; Anita Trauninger; Laszlo Szereday; Zsolt Illes πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 330 KB

## Abstract ## Introduction: Enzyme replacement therapy (ERT) in ultra‐orphan Pompe disease generates anti‐rhGAA antibodies, which may interfere with efficacy. ## Methods: rhGAA‐specific T‐cell responses were examined at different time‐points in 6 Hungarian patients treated with rhGAA and compar