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Immunologic responses to a murine mammary adenocarcinoma. II. Monocyte effector activation by humoral factors

✍ Scribed by Yasuhiro Yamamura

Publisher
John Wiley and Sons
Year
1977
Tongue
French
Weight
655 KB
Volume
19
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Sera from DBA/2 mice bearing a syngeneic T1699 mammary adenocarcinoma not only induced specific antibody‐dependent cellular cytotoxicity (ADCC) mediated by monocytes (and/or macrophages) but also armed (activated) such effector cells into specific killer cells in vitro. Removal of specific anti‐tumor antibody (IgG~2a~ subclass) by absorption with T1699 cells abolished the ADCC activity at the level of target cell coating but did not alter the level of effector‐arming activity. Fractionation on Sephadex G‐20 indicated more than one factor capable of inducing specific monocyte‐mediated lysis of target cells in vitro, including immune complexes, free IgG~2a~ 7S antibody (ADCC), and another factor(s) with a molecular weight very close to that of 7S immunoglobulins.

📜 SIMILAR VOLUMES

Immunological responses to a murine mamm
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## Abstract DBA/2 mice bearing a syngeneic mammary adenocarcioma T1699 produced high levels of tumor‐specific antibody, detected by indirect immunofluorescence and subsequently identified as the IgG~2a~ subclass. Tumor‐bearer sera passively administered to normal recipients protected the animals fr