Immunological responses to a murine mammary adenocarcinoma. outgrowth of pulmonary occult metastases induced by immunosuppressive perturbations

✍ Scribed by Yasuhiro Yamamura; Paul G. Braunschweiger; K. Ramananda Madyastha; Julian W. Proctor

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: French
• Weight: 531 KB
• Volume: 33
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910330113

✦ Synopsis

Abstract

Intravenously (i.v.) or subcutaneously (s.c.) injected T1699 tumor cell subpopulations (Ts, and TL1–1) were destroyed more rapidly in BALB/c nu/nu athymic mice than in syngeneic DBA/2J mice. The number of artificial pulmonary metastases of TL1–1 tumors was significantly lower, and the growth rate of s.c. Ts, and TL1–1 tumors was correspondingly slower in the nude mice. No macroscopic outgrowth of pulmonary metastases of Ts tumors was detected in either group of s.c. tumor‐bearers, even though the s.c. tumors progressed and killed the hosts. Unexpectedly, however, s.c. implantation in normal DBA/2J mice of lung homogenates not only from DBA/2J but also from s.c. Ts tumor‐bearing BALB/c nu/nu mice produced tumors, suggesting that significant numbers of clonogenic Ts cells were present in the lungs of animals without spontaneous outgrowth of pulmonary metastases. Perturbations of s.c. Ts tumor‐bearing DBA/2J or BALB/c nu/nu mice with immunosuppressive drugs or with anti‐mouse thymocyte serum, respectively, induced rapid outgrowth of pulmonary metastases.