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Immunoliposomal fenretinide: a novel antitumoral drug for human neuroblastoma

✍ Scribed by L. Raffaghello; G. Pagnan; F. Pastorino; E. Cosimo; C. Brignole; D. Marimpietri; E. Bogenmann; M. Ponzoni; P.G. Montaldo


Book ID
117467748
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
109 KB
Volume
197
Category
Article
ISSN
0304-3835

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We have designed a new dextran-peptide-methotrexate conjugate to achieve tumor-targeted delivery of chemotherapeutics. The dextran carrier was selected to allow passive targeting and enhanced permeation and retention (EPR). The peptide linker has also been optimized to allow drug release in the pres