✦ LIBER ✦

Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease

✍ Scribed by N. Horwood; D. C. Davies

Book ID: 104658785
Publisher: Springer
Year: 1994
Tongue: English
Weight: 590 KB
Volume: 425
Category: Article
ISSN: 1432-2307
DOI: 10.1007/bf00193951

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✦ Synopsis

Changes in cerebral microvessel ultrastructure have been reported to occur in Alzheimer's disease (AD). In order to investigate whether these changes are associated with compromised blood-brain transport mechanisms, hippocampal formation sections from AD and age-matched normal brains were immunolabelled with an antibody to the GLUT-1 glucose transporter protein. GLUT-1 immunolabelling of microvessel endothelium was significantly reduced in the AD compared to normal hippocampal formation. Thus, AD is associated with a reduction in cerebral microvessel endothelium glucose transporter content, which may result in decreased glucose availability to the brain.

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