Protein kinase C (PKC) plays a key role in the transduction of extracellular signals across the membrane. The PKC family consists of six unique genes that give rise to at least seven different PKC subtypes which form two groups, the classical subtypes (a, bI, bII, g) and a novel group of at least th
Immunohistological identification of protein kinase C isozymes in normal and psoriatic epidermis
โ Scribed by S. Inohara; Y. Tatsumi; Y. Tanaka; H. Tateishi; S. Sagami
- Publisher
- Springer-Verlag
- Year
- 1988
- Tongue
- English
- Weight
- 332 KB
- Volume
- 280
- Category
- Article
- ISSN
- 0340-3696
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In order to gain insight into the biological function of a PKC iso-enzyme, the protein kinase C, we analyzed the expression pattern of this protein in mouse epidermis and keratinocytes in culture. Daily analysis of neonatal mouse epidermis immediately after birth showed a time-dependent reduction in
## Abstract Protein kinase C (PKC) represents a family of structurally related Ser/Tre kinases which are involved in mitogenic signalling and may contribute to human neoplasia. To address this issue, the messenger RNA and protein levels of PKC isoenzymes ฮฑ and ฮฒ were analyzed in several human sarco