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Immunohistological evaluation of Ki-67, p63, CK19 and p53 expression in oral epithelial dysplasias

✍ Scribed by T. Takeda; K. Sugihara; Y. Hirayama; M. Hirano; J-I. Tanuma; I. Semba


Book ID
111254960
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
533 KB
Volume
35
Category
Article
ISSN
0904-2512

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Oral squamous cell carcinoma develops through a series of precancerous stages manifested at the microscopic level as epithelial dysplasia. Mutation of the p53 tumour suppressor gene is thought to be an important component of oral carcinogenesis. p53 regulates cell proliferation and DNA repair by inh