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Immunohistochemical study on the distribution of nitrotyrosine and neuronal nitric oxide synthase in aged rat cerebellum

✍ Scribed by Yoon Hee Chung; Chung Min Shin; Kyeung Min Joo; Myeung Ju Kim; Choong Ik Cha


Book ID
113998490
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
487 KB
Volume
951
Category
Article
ISSN
0006-8993

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A free radical, nitric oxide (NO), besides being a messenger molecule in the brain, becomes a neurotoxin if overproduced. We recently reported that methylmercury (MeHg) induces neuronal NO synthase (nNOS) in Purkinje cells. In the present study, we examined the distribution and the mechanism of nNOS