Immunohistochemical analysis of p53, cyclin D1,Rb,C-fos and N-ras genes expression in hepatocellular carcinoma in Iran
โ Scribed by Mohammad Reza Zali; Seyed Javad Mirhassani Moghaddam; Saeed Samie; Negin Shahid; Alireza Keramati; Ehsan Nobakht Haghighi; Mohammad Ali Daneshmand
- Book ID
- 119394594
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 25 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0002-9270
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## BACKGROUND. Epidemiologic studies have indicated that environmental and personal habits, particularly tobacco use and alcohol abuse, are major etiologic factors in the induction and progression of head and neck squamous cell carcinomas (HNSCC). Molecular studies have focused on HNSCC related to
Cyclin D1 is a major positive regulator of the G 1 restriction point promoting inactivation of the retinoblastoma protein (RB). The cyclin D1 gene is rearranged, amplified and/or over-expressed in several human neoplasms. In the present series of 64 human breast carcinomas, cyclin D1 amplification (