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Immunoglobulins from motoneurone disease patients enhance glutamate release from rat hippocampal neurones in culture

✍ Scribed by Pavle R. Andjus; Zorica Stevic-Marinkovic; Enrico Cherubim

Book ID
111117691
Publisher
Cambridge University Press
Year
1997
Tongue
English
Weight
812 KB
Volume
504
Category
Article
ISSN
0022-3751

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Excess administration of glutamate is known to induce Ca 21 overload in neurons, which is the first step in excitotoxicity. Although some reports have suggested a role for Mg 21 in the excitotoxicity, little is known about its actual contribution. To investigate the role of Mg 21 in the excitotoxici