Immunoglobulin light chain gene translocations in non-Hodgkin’s lymphoma as assessed by fluorescence in situ hybridisation
✍ Scribed by Yoshiko Fujimoto; Kenichi Nomura; Shuji Fukada; Daisuke Shimizu; Kazuho Shimura; Yosuke Matsumoto; Shigeo Horiike; Kazuhiro Nishida; Chihiro Shimazaki; Masafumi Abe; Masafumi Taniwaki
- Book ID
- 114794324
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 603 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0902-4441
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## Abstract Sixty consecutive evaluable specimens from patients with non‐Hodgkin's lymphoma (NHL) were studied for the incidence of polysomy of chromosome 12 by fluorescence in situ hybridization (FISH) with probes for the repetitive DNA sequence in the centromeric region of chromosome 12. Thirty‐s
Cytogenetic studies have shown rearrangements of the Ig heavy chain (IGH) gene at 14q32 in 10-60% of patients with multiple myeloma (MM) or primary plasma cell leukemia (PCL). Analysis of MM patients and human myeloma cell lines (HMCL) using interphase fluorescence in situ hybridization (FISH) and m