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Immunoglobulin kappa gene repertoire and somatic hypermutation patterns in follicular lymphoma

✍ Scribed by Tatjana Smilevska; Eugenia Tsakou; Anastasia Hadzidimitriou; Vasilis Bikos; Niki Stavroyianni; Nikolaos Laoutaris; Αthanasios Fassas; Achilles Αnagnostopoulos; Theodora Papadaki; Chrysoula Belessi; Kostas Stamatopoulos

Book ID
116304612
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
204 KB
Volume
41
Category
Article
ISSN
1079-9796

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## A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro The functional immunoglobulin (Ig) genes of B lymphocytes undergo somatic mutations during immune responses. These mutations modify the antigen binding site of the immunoglobulins, thereby enhancin