✦ LIBER ✦

Immunoglobulin gene rearrangements in acute lymphoblastic leukemia with the 9;II translocation

✍ Scribed by Dr. Adonis N. Lorenzana; Charles M. Rubin; Michelle M. Le Beau; James Nachman; Patrick Connolly; Uma Subramanian; F. Leonard Johnson; Timothy W. McKeithan

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 509 KB
Volume: 3
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870030113

No coin nor oath required. For personal study only.

✦ Synopsis

The recurring chromosomal 9; I I translocation [t(9; I I ) (p22;q23)] typically is associated with acute monoblastic leukemia, but a number of patients with acute lymphoblastic leukemia also have been reported to have the t(9;l I). To investigate the cell lineage in the latter cases, we analyzed DNA from the leukemic cells of an 8-year-old girl with acute lymphoblastic leukemia and a t(9; I I) for rearrangements of the immunoglobulin and T-cell receptor genes. Rearrangements of both immunoglobulin heavy-chain loci and of one lambda light-chain gene were detected, as well as deletions affecting both alleles of the kappa light-chain genes; T-cell receptor genes were in germline configuration. These results provide further evidence that the 9; I I translocation is not limited to myeloid lineage leukemia and may be observed in acute lymphoblastic leukemia.

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