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Immunoglobulin Class Switch Recombination Machinery: Progress and Challenges

✍ Scribed by Ke Zhang

Book ID
115593731
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
82 KB
Volume
95
Category
Article
ISSN
1090-2341

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## Abstract Immunoglobulin class switch recombination (CSR) is initiated by activation‐induced cytidine deaminase (AID), an enzyme that deaminates cytidine residues in single‐stranded DNA. U:G mismatches created by AID are processed to produce lesions that recruit and activate DNA damage response p