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Immunoglobulin class-switch DNA recombination: induction, targeting and beyond

✍ Scribed by Xu, Zhenming; Zan, Hong; Pone, Egest J.; Mai, Thach; Casali, Paolo

Book ID
111897418
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
738 KB
Volume
12
Category
Article
ISSN
1474-1741

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## Abstract Immunoglobulin class switch recombination (CSR) is initiated by activation‐induced cytidine deaminase (AID), an enzyme that deaminates cytidine residues in single‐stranded DNA. U:G mismatches created by AID are processed to produce lesions that recruit and activate DNA damage response p