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Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

โœ Scribed by Chaudhuri, Jayanta; Alt, Frederick W.

Book ID
109954571
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
239 KB
Volume
4
Category
Article
ISSN
1474-1741

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## Abstract Poly(ADPโ€ribosyl)ation is a postโ€translational modification occurring in the nucleus. The most abundant and bestโ€characterized enzyme catalyzing this reaction, poly(ADPโ€ribose) polymerase 1 (PARP1), participates in fundamental nuclear events. The enzyme functions as molecular โ€œnick sens