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Immunogenicity of embryonic antigens associated with chemically induced rat tumours

✍ Scribed by R. W. Baldwin; Dorothy Glaves; B. M. Vose

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
559 KB
Volume
13
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Immunization of syngeneic rats with mid‐gestation rat embryo cells failed to elicit resistance to challenge with chemically‐induced rat hepatomas and sarcomas. In addition, lymphoid cells from multiparous female rats were uniformly ineffective in transferring tumour immunity to normal rats. In spite of this apparent lack of immunogenicity, serum and lymph‐node cells from animals immunized with tumour were cytotoxic for cultured embryo cells known to share embryonic antigen specificities with tumour cells. It is concluded that, although immunogenic, the tumour‐associated embryonic antigen does not function as a tumour rejection antigen.

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