✦ LIBER ✦

Immunogenicity of a single dose of trivalent influenza vaccine including A/Philippines (H3N2): Results of a field trial

✍ Scribed by Dr. Manfred S. Green; Colin Block; Lotte Rannon

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 393 KB
Volume: 19
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890190209

No coin nor oath required. For personal study only.

✦ Synopsis

During 1982, a new A(H3N2) influenza ViNS subtype, A/Philippines/2/82, was identified, and this strain was combined with previous A(HlN1) and B influenza virus strains in the trivalent inactivated vaccine recommended for the 1983-1984 influenza season. Prior to the widescale use of this vaccine in Israel, a group of 106 young male soldiers was vaccinated under controlled conditions. Before vaccination, antibody titers greater than or equal to 1:40 were found in 14.1% against A/Philippines (H3N2), 18.1 % against A/England/333/80 (HlNl), and 13.3 % against B/Singapore/222/79. Two weeks following vaccination, 78.9% of the vaccinees for whom repeated blood samples were available, had antibody titers in this range for A/Philippines (H3N2), 92.9% for A/England (HlNl), and 80.0% for BiSingapore. The vaccine was only mildly reactogenic, and there were no cases of absence from work following vaccination. Thus the antibody response of young subjects to a single dose of a vaccine containing a new A(H3N2) subtype was found to be satisfactory, and the side effects experienced were minimal.

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