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Immunoelectron microscopical localization of the catalytic subunit of cAMP-dependent protein kinases in brain microtubules and neurofilaments

✍ Scribed by Bernhard Trinczek; Gerhild Schwoch

Book ID: 115923646
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 989 KB
Volume: 277
Category: Article
ISSN: 0014-5793
DOI: 10.1016/0014-5793(90)80835-7

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## Abstract The active site of the mammalian cAMP‐dependent protein kinase catalytic subunit (C‐subunit) has a cluster of nonconserved acidic residues—Glu127, Glu170, Glu203, Glu230, and Asp241—that are crucial for substrate recognition and binding. Studies have shown that the Glu230 to Gln mutant