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Immunocytochemical staining of p16ink4a protein as an adjunct test in equivocal liquid-based cytology

โœ Scribed by Eun Kyoung Shin; Sa Ra Lee; Mi Kyoung Kim; Eun Ji Kang; Woong Ju; Shi Nae Lee; Woon Sup Han; Seung Cheol Kim


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
141 KB
Volume
36
Category
Article
ISSN
8755-1039

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## Abstract Cytological screening for cervical cancer is hampered by high false negative rates. Interโ€observer reproducibility needs optimizing. The potential of p16^INK4a^ as a biomarker for cervical lesions was examined in a study of liquidโ€based cytology (LBC), HPV DNA testing by MY09/MY11 conse

Immunohistochemical detection of p16INK4
โœ Liu, Haiyan ;Shi, Jianhui ;Wilkerson, Myra ;Huang, Yajue ;Meschter, Steven ;Dupr ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 493 KB ๐Ÿ‘ 1 views

## BACKGROUND. Colposcopy biopsy procedure is a standard recommendation for atypical squamous cell cannot exclude high-grade lesion (ASC-H) in abnormal Papanicolaou smears. p16 (p16INK4a), a cell cycle regulator, has been shown to be overexpressed in squamous dysplasia. To further improve the diag