Evaluation of a nuclear score for p16INK4a-stained cervical squamous cells in liquid-based cytology samples
β Scribed by Wentzensen, Nicolas ;Bergeron, Christine ;Cas, Frederic ;Eschenbach, Denise ;Vinokurova, Svetlana ;von Knebel Doeberitz, Magnus
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 183 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0008-543X
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## BACKGROUND. Colposcopy biopsy procedure is a standard recommendation for atypical squamous cell cannot exclude high-grade lesion (ASC-H) in abnormal Papanicolaou smears. p16 (p16INK4a), a cell cycle regulator, has been shown to be overexpressed in squamous dysplasia. To further improve the diag
## Abstract Even though p16^INK4a^ (p16) immunocytochemistry has proven a useful accessory tool verifying the identification of atypical squamous cells of undetermined significance (ASCβUS) categorized smears, the procedure still has limitations. To date few studies examining the usefulness of p16
Diffuse overexpression of p16 INK4a in basal and parabasal cells of cervical epithelium is a hallmark of human papillomavirusmediated transformation. Focal p16 INK4a expression is occasionally observed in nondysplastic epithelium. In normal cells, expression of p16 INK4a triggers cell cycle arrest.