## Abstract The hormones which support growth, in vitro, of normal, neonatal human foreskin fibroblasts were determined. Wheresas thrombin and hydrocortisone were major growth stimulants, plateletβderived growth factor was not. Human foreskin fibroblasts grew in a serumβfree, biochemically defined
Immunocytochemical detection of surface binding and uptake of platelet-derived growth factor in human fibroblasts using cryo-ultramicrotomy
β Scribed by A.J.M. van den Eijnden-van Raaij; P. van Maurik; E.J.J. van Zoelen; J. Boonstra
- Book ID
- 103684221
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 96 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0304-3991
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We have previously found that stimulation of normal neonatal fibroblasts with PDGF or EGF leads to a transient induction of PDGF Aβchain mRNA and the synthesis of PDGFβAA proteins. This finding may imply the existence of an autocrine feedback mechanism to amplify the mitogenic signal un
## Abstract Plateletβderived growth factor (PDGF) is a potent mitogenic and chemotactic cytokine, and PDGFβC is a novel growth factor belonging to the PDGF family. In this study, to determine whether this growth factor can contribute to fibrosis and tissue remodeling, we examined the effect of PDGF
The growth regulation of human diploid fibroblasts by platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin-like growth factor I (IGF-I) (somatomedin C), dexamethasone, and transferrin was investigated in a serumfree, chemically defined culture system. Cell-cycle kinetic para