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Immunocompetence may be important in the effectiveness of Mectizan® (ivermectin) in the treatment of human onchocerciasis

✍ Scribed by Magdi M.M Ali; Moawia M Mukhtar; Omer Z Baraka; Mamoun M.A Homeida; Musa M Kheir; Charles D Mackenzie

Book ID: 117006907
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 117 KB
Volume: 84
Category: Article
ISSN: 0001-706X
DOI: 10.1016/s0001-706x(02)00117-1

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Ivermectin, at the standard dose of 150 cLg/kg bodyweight, does not kill the adult worms of Onchocerca volvulus and does not disrupt embryogenesis or spermatogenesis. Repeated standard doses, if maintained, arrest microfilarial production but result in only a mild-to-modest macrofilaricidal effect.