๐”– Bobbio Scriptorium
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Immunization of mice with an avirulent pseudohyphal form of Cryptococcus neoformans

โœ Scribed by Robert A. Fromtling; Rebecca Blackstock; Nancy K. Hall; Glenn S. Bulmer


Publisher
Springer Netherlands
Year
1979
Tongue
English
Weight
208 KB
Volume
68
Category
Article
ISSN
0301-486X

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## Three pseudohyphal isolates of Cryptococcus neoformans were inoculated intracranially into mice. Four weeks postinoculation the animals showed no symptoms of disease and the number of viable cells per brain decreased to Zero. Possible roles of pseudohyphal forms of C. neoforroans in the immunol

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A close correlation was observed between body weight and length of the survival time of mice inoculated intravenously (i.v.)with Cryptococeus neoformans (p < 0.001). An endotoxic substance of C. neoformans (Cr-ET) increased the susceptibility of mice to i.v. infection of C. neoformans only when more

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