✦ LIBER ✦
Factors affecting experimental infection with Cryptococcus neoformans in mice with special reference to an endotoxic substance of C. neoformans
✍ Scribed by Takashi Kobayashi; Osamu Kato; Izumi Nakashima; Nobuo Kato
- Publisher
- Springer Netherlands
- Year
- 1975
- Tongue
- English
- Weight
- 412 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0301-486X
No coin nor oath required. For personal study only.
✦ Synopsis
A close correlation was observed between body weight and length of the survival time of mice inoculated intravenously (i.v.)with Cryptococeus neoformans (p < 0.001). An endotoxic substance of C. neoformans (Cr-ET) increased the susceptibility of mice to i.v. infection of C. neoformans only when more than 50 #g of Cr-ET was injected i.v. 24 hours before infection. Intraperitoneal (i.p.) administration of dimethyl sulfoxide which is found to enhance bacterial infection did not enhance death rate of mice infected i.p. with C. neoformans.