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Immune system dysregulation in the α1,2-fucosyltransferase transgenic mouse model of colitis

✍ Scribed by Miller, Ashley M.; Elliott, Peter R.; Connell, William; Brown, Steven; Murray-Segal, Lisa; Desmond, Paul V.; Malin, Mark; Gill, Jason; Boyd, Richard; D'Apice, Anthony Jf

Book ID
124135090
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
185 KB
Volume
120
Category
Article
ISSN
0016-5085

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## Background: The G protein alpha subunit type-2 (G␣ i 2)-deficient mouse develops inflammatory bowel disease (IBD) with increased severity in mice on a 129SvEv (129) background compared to the C57BL/6 (B6) background. Since dendritic cells (DCs) are key cells of innate immunity, we determined wh