✦ LIBER ✦

Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic

✍ Scribed by William SM Wold; Konstantin Doronin; Karoly Toth; Mohan Kuppuswamy; Drew L Lichtenstein; Ann E Tollefson

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 780 KB
Volume: 11
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(99)80064-8

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✦ Synopsis

Adenoviruses encode proteins that block responses to intsrferons, intrinsic cellular apoptosis, killing by CD8+ cytotoxic T lymphocytes and killing by the death ligands TNF, Fas ligand and TRAIL. The viral proteins are believed to prolong acute and persistent adenovirus infections. The proteins may prove useful in protecting adenovirus gene therapy vectors and transplanted cells from the immune system.

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