✦ LIBER ✦

Immune response to hepatitis B revaccination

✍ Scribed by Dr. Wolfgang Jilg; Marion Schmidt; Friedrich Deinhardt

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 416 KB
Volume: 24
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890240404

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✦ Synopsis

Two hundred and twelve individuals who failed to respond or responded poorly to hepatitis B vaccination or whose anti-HBs levels had dropped below 10 IU/L at follow-up were revaccinated. Only 18% of initial nonresponders, but 96% of those who responded initially, developed anti-HBs above 10 IU/L after revaccination. In 85% of vaccinees, anti-HBs titres after a fourth immunization were significantly higher than after completion of the first full immunization course, and despite a steeper decline of antibody levels after revaccination, anti-HBs seemed to persist better than after the initial course of three inoculations. All individuals who responded initially and in whom anti-HBs had become undetectable developed antibodies. Response to booster doses was seen after three to five days, and a fifth inoculation given to 23 individuals induced even better responses.

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