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Immune response to cancer and its regulation in regional lymph nodes

✍ Scribed by Rongxiu Zheng; Suyu Shu

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
88 KB
Volume
103
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

Regional draining lymph nodes (LNs) play a pivotal role in initiating immune responses. However, the presence of metastases may compromise their normal immunological function. Preclinical studies indicate that despite metastases, early tumor‐draining LNs are still a rich source of sensitized T cells. Recently, we found that dendritic (DC)‐tumor fusion hybrids were capable of stimulating therapeutic T‐cell generation in the LN. However, this response is regulated by a tumor‐specific suppression mechanism(s). Reversal of these dysfunctions would help the success of immunotherapy. J. Surg. Oncol. 2011;103:550–554. Β© 2011 Wiley‐Liss, Inc.

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