Immune-inflammatory mechanisms in IFNγ-mediated anti-tumor activity
✍ Scribed by Charles S. Tannenbaum; Thomas A. Hamilton
- Book ID
- 112264989
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 366 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1044-579X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Eight patients with epithelial ovarian carcinoma persisting after chemotherapy, selected for having a residual tumor no larger than I cm in diameter, were treated intra‐peritoneally (i.p.) with recombinant interferon‐γ twice weekly for 3 months. Toxicity consisted of fever and malaise i
IL-15 and IL-12 display anti-tumor activity in different models and IFN-gamma has been reported as a secondary mediator of both IL-12 and IL-15 effects. TS/A murine adenocarcinoma cells were engineered to secrete IL-12, IL-15 or both cytokines. TS/A cells secreting IL-15 (TS/A-IL-15) displayed a red