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The anti-tumor activity of anti-CTLA-4 is mediated through its induction of IFNγ

✍ Scribed by Timothy J. Paradis; Eugenia Floyd; Jeff Burkwit; Susan H. Cole; Brandon Brunson; Eileen Elliott; Steven Gilman; Ronald P. Gladue

Book ID
105968452
Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
235 KB
Volume
50
Category
Article
ISSN
0340-7004

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## Abstract Downregulation of major histocompatibility complex (MHC) molecules by tumor cells impairs cellular immune recognition and contributes to inefficient cell‐mediated tumor eradication. Low or lack of expression of MHC molecules is frequently observed in early developmental or embryonically