𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Immortalized human microglial cell line: Phenotypic expression

✍ Scribed by Atsushi Nagai; Seiji Mishima; Yuri Ishida; Hiroto Ishikura; Takayuki Harada; Shotai Kobayashi; Seung U. Kim

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
288 KB
Volume
81
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Microglia are a major neuroglial component of the CNS, playing an important role as resident immunocompetent and phagocytic cells in the CNS in the event of injury and disease. To understand the role of microglia in the CNS in health and diseases, we have recently established an immortalized clonal cell line of human microglia, HMO6, from human embryonic telencephalon tissue by using a retroviral vector encoding v‐myc. This immortalized microglia HMO6 cell line exhibits cell‐type‐specific antigens for microglia, including CD11b (Mac‐1), CD68, CD86 (B7‐2), HLA‐ABC, HLA‐DR, and RCA‐1 lectin, and actively phagocytoses latex beads. Β© 2005 Wiley‐Liss, Inc.

πŸ“œ SIMILAR VOLUMES

An immortalized cell line expresses prop
An immortalized cell line expresses properties of activated microglial cells
✍ V. Bocchini; R. Mazzolla; R. Barluzzi; E. Blasi; P. Sick; H. Kettenmann πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 605 KB

## Abstract Murine cultured microglial cells were immortalized after infection with a v‐raf/v‐myc recombinant retro‐virus. This immortalized cell line (BV‐2) shares properties with body macrophages with respect to the antigen profile, their phagocytic capacity and antimicrobial activity. BV‐2 cells

Immortalized cell lines from mouse xiphi
Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype
✍ Manas K. Majumdar; Priya S. Chockalingam; Ramesh A. Bhat; Richard Sheldon; Crist πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 333 KB

## Abstract Chondrocytes are unique to cartilage and the study of these cells in vitro is important for advancing our understanding of the role of these cells in normal homeostasis and disease including osteoarthritis (OA). As there are limitations to the culture of primary chondrocytes, cell lines

Serial analysis of gene expression in a
Serial analysis of gene expression in a microglial cell line
✍ Haruhisa Inoue; Makoto Sawada; Akihide Ryo; Hiroshi Tanahashi; Toru Wakatsuki; A πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 121 KB πŸ‘ 2 views

We used the serial analysis of gene expression (SAGE) method to systematically analyze transcripts present in a microglial cell line. Over 10,000 SAGE tags were sequenced, and shown to represent 6,013 unique transcripts. Among the diverse transcripts that had not been previously detected in microgli

Expression of gangliosides in an immorta
Expression of gangliosides in an immortalized neural progenitor/stem cell line
✍ Keiji Suetake; Sean S. Liour; Tewin Tencomnao; Robert K. Yu πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 301 KB

Glycosphingolipids (GSLs) are known to play important roles in cellular growth and differentiation in the nervous system. The change in expression of gangliosides is correlated with crucial developmental events and is evolutionarily conserved among many vertebrate species. The emergence of neural pr