## Abstract __Herpesvirus saimiri__ (__Saimiriine herpesvirus__‐2), a γ2‐herpesvirus (rhadinovirus) of non‐human primates, causes T‐lymphoproliferative diseases in susceptible organisms and transforms human and non‐human T lymphocytes to continuous growth in vitro in the absence of stimulation. T c
Immortalization of human T cells by herpesvirus saimiri
✍ Scribed by Edgar Meinl; Reinhard Hohlfeld; Hartmut Wekerle; Bernhard Fleckenstein
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 816 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0167-5699
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## Abstract __Herpesvirus saimiri (H. saimiri)__ ‐transformed cells contain both types of viral DNA, unique L‐DNA and highly repetitive H‐DNA. DNA from spleen and lymph‐node autopsies of two tumor‐bearing marmoset monkeys contained 0.14–0.75 / viral L‐DNA and 0.115–1.08 / H‐DNA. This amount of H‐DN
Herpesvirus saimiri has characteristics that make it amenable to development as a gene therapy vector. The viral genome is thought to be capable of accommodating large quantities of heterologous DNA while the virus itself can infect many different cell types. Virus infection has been shown in many c