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Immortalization of human mammary epithelial cells by SV40 large T-antigen involves a two step mechanism

โœ Scribed by Brigitte A. Van Der Haegen; Jerry W. Shay


Book ID
112803527
Publisher
Society for In Vitro Biology
Year
1993
Tongue
English
Weight
423 KB
Volume
29
Category
Article
ISSN
1475-2689

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## BACKGROUND. The available human prostate cancer cell lines that are metastatic in athymic nude mice all have complex, highly aneuploid karyotypes. Other prostatic cells immortalized by transforming genes of SV40 or HPV and converted to tumorigenicity by additional genetic manipulation are not r