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Immobilized microorganisms in the reduction of ethyl benzoylacetate

✍ Scribed by Aline de Souza Ramos; Joyce Benzaquem Ribeiro; Leonardo Vazquez; Sorele Batista Fiaux; Selma Gomes Ferreira Leite; Maria da Conceição Klaus V. Ramos; Francisco Radler de Aquino Neto; O.A.C. Antunes

Book ID
104097084
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
196 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

The enantioselective reduction of ethyl benzoylacetate (EBA) into ethyl (S)-3-hydroxy-3-phenylpropanoate (S-HPPE) by nine yeast strains and three filamentous fungi strains is described. The conversion obtained was in the range 0-89% and the enantiomeric excess was 100% in many cases. Conversion levels were higher when the reduction was performed with microorganisms immobilized in calcium alginate and enantioselectivity remained excellent. Some reaction's conditions of bioreduction by immobilized cells of Rhodotorula rubra were studied using a 2 5-2 fractional factorial design.

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