Immobilized IL-2 preserves the viability of an IL-2 dependent cell line
β Scribed by Joseph I. Horwitz; Mehmet Toner; Ronald G. Tompkins; Martin L. Yarmush
- Book ID
- 118384621
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 997 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0161-5890
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A selected clone from an IL-2-dependent human T-cell line was persistently propagated in the presence of phorbol esters with the ability to activate protein kinase C (PKC), such as 12-0-tetradecanoylphorbol-I 3-acetate (TPA) or phorbol-12,1.3-dibutylate (PDBu). Thus, a TPA(PD6u)-dependent T-cell lin
A continuous cell line was established from the blood of a patient (HH) with an aggressive cutaneous T-cell leukemia/ lymphoma who lacked antibodies to human T lymphotrophic virus, type 1. The immunophenotype of the cultured cells was CD2+, CD3+, CD4+, CD5+, CD8-, DR' and CD25-(Tac, IL-2 receptor a