diphosphate (UDP)-glucuronosyltransferase (UGT) and re-Significant controversy exists regarding the regulaquires UDP-glucuronic acid (UDP-GlcUA), which serves as tion of glucuronidation during the process of hepatic the donor substrate of the conjugating sugar. The active site regeneration. We used
β¦ LIBER β¦
Immobilized hepatic microsomes for the synthesis of glucuronides
β Scribed by S. S. Sofer
- Book ID
- 112964365
- Publisher
- Springer-Verlag
- Year
- 1976
- Tongue
- English
- Weight
- 186 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0273-2289
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Glucuronidation of carboxylic acids, primarily catalyzed by hepatic UDPglucuronosyltransferases, is an important phase II metabolic pathway functioning in detoxification. Acyl glucuronides of 2-aryl propionates, however, can form covalently bound protein adducts, which may generate hypersensitive re
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