diphosphate (UDP)-glucuronosyltransferase (UGT) and re-Significant controversy exists regarding the regulaquires UDP-glucuronic acid (UDP-GlcUA), which serves as tion of glucuronidation during the process of hepatic the donor substrate of the conjugating sugar. The active site regeneration. We used
Hepatic regeneration is associated with preservation of microsomal glucuronidation
β Scribed by WF Zakko; RM Green; JL Gollan; CL Berg
- Book ID
- 118686469
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 327 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0270-9139
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The liver responds to injury with regulated tissue regeneration. During early regeneration, the liver accumulates fat. Neither the mechanisms responsible for nor the functional significance of this transient steatosis have been determined. In this study, we examined patterns of gene expression assoc
The disposition of oral oxazepam was investigated in seven patients with decompensated cirrhosis and encephalopathy and in nine healthy individuals to further examine the hypothesis of preservation of glucuronidation in liver disease. The patients showed a severe reduction in the quantitative liver