Immobilized aldehydes and olefins in the solid support synthesis of tetrahydroquinolines via a three component condensation
โ Scribed by Alexander S. Kiselyov; Leon Smith II; Alex Virgilio; Robert W. Armstrong
- Book ID
- 104208674
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 607 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4020
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๐ SIMILAR VOLUMES
Solid support synthesis of polysubstituted tetrahydroquinolines is described. The procedure is based on a three-component condensation involving immobilized derivatives of 4-aminophenylalanine, aldehydes, alkenes and Yb(OTf) 3 as a catalyst. The methodology is further expanded to the solid support s
An efficient ZrCl 4 catalyzed ortho-hydroxyalkylation of phenols with aldehydes promoted by 3,5-bis (trifluoromethyl)phenyl boronic acid, leading to the formation of 2-aryl-1,3,2-aryldioxaborins was investigated and optimized. The reaction afforded the desired aryldioxaborins in good to excellent yi