Immediate antigen-specific effector functions byTCR-transgenic CD8+ NKT cells
✍ Scribed by Gerhard Wingender; Martina Berg; Frank Jüngerkes; Linda Diehl; Barbara A. Sullivan; Mitchell Kronenberg; Andreas Limmer; Percy A. Knolle
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 439 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0014-2980
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## Abstract The requirements for the conversion of CD8^+^ memory T cells into effector class I major histocompatibility complex (MHC) K^d^−restricted cytotoxic T (T~c~) cells __in vitro__ have been studied. Purified CD8^+^splenocytes from influenza A/WSN‐primed BALB/c (H‐2^d^) mice stimulated with
## Abstract CD8^+^ T cells are critical for protecting the body from infectious disease. To achieve this protection, CD8^+^ T cells must undergo a highly involved process of differentiation that involves the activation of naïve/quiescent cells followed by robust rounds of cell division and the acqu