Iminophosphorane-Mediated Synthesis of Fused Perimidines: Preparation of Quinazolino[3,4-a]perimidine Derivatives
✍ Scribed by Molina, Pedro ;Alías, Asunción ;Balado, Ana ;Arques, Antonio
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 495 KB
- Volume
- 1994
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
An aza‐Wittig‐type reaction of iminophosphoranes 2 and 3, derived from 2‐(2‐azidophenyl)‐1,2‐dihydroperimidine and 2‐(2‐azidophenyl)perimidine, respectively, with isocyanates, carbon dioxide, carbon disulfide and acyl chlorides provides 6‐substituted quinazolino[3,4‐α]perimidines 4–10. magnified image
📜 SIMILAR VOLUMES
## Abstract Aza Wittig reaction of bis(iminophosphorane) 3 with two equivalents of aryl isocyanates directly provided the bicyclic guanidines 4. However, 3 undergoes intramolecular aza Wittig reaction on thermal treatment to give the iminophosphorane 6 derived from the 2‐(__o__‐azidophenyl)‐4(3__H_
In a recent communication'). we reported the synthesis of some biologically interesting 1-substituted 3-(2-perimidyl)-ureas starting from 2-aminoperimidine (la). Because of the presence of a 1,3-dinucleophilic center in this molecule, l a might undergo cyclocondensation with appropriate dielectrophi