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Imino-Bridged heterocycles. V . Synthesis of 6,11-dimethyl-1 1H-benzo[5,6]cyclohepta[1,2-c]pyridin-6,11-imine by a regiospecific amide to olefin cyclization

โœ Scribed by Daniel G. Brenner; Wasyl Halczenko; Kenneth L. Shepard


Book ID
112128112
Publisher
Journal of Heterocyclic Chemistry
Year
1986
Tongue
English
Weight
319 KB
Volume
23
Category
Article
ISSN
0022-152X

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The carbanion derived from 8,1 l-dichloro-6,1 l-dihydro-5H-benzo [5,6]cyclohepta[l,2-bl pyridine (3) reacts with methyl acrylate to form the C. spirocyclopropane carboxylic acid methyl ester 6. Compound 6 was converted in five steps to the N-methyl 2'-ethylamino spirocyclopropane 2 (R=H) which was r