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Imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase

✍ Scribed by David M. Fink; M.G. Palermo; Gina M. Bores; Francis P. Huger; Barbara E. Kurys; Michael C. Merriman; Gordon E. Olsen; Wayne Petko; Gerard J. O'Malley

Book ID: 103983333
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 346 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00072-8

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✦ Synopsis

A series of irrfino 1,2,3,4-tetrahydrocyclopent [b]indole caltmn~tes was prepared and evaluated as dual acetyichollm, stem~ (ACHE) and monoan-fine oxida~ (MAO) inhibitors. Halogen substitution ortho to the cartmn-me functionality in the eight position resulted in a significant increase in binding affinity for both AChE and MAO-A.

Alzhekner's Disease (AD) is a neurodegenerative disorder that is the rmjor cause of dementia amongst the elderly.

This disease affects about 2% of the population over the age of 65, and up to 50% of the population over the age of 85. l As general heakh care improves and the proportion of elderly people in the population increases, the number of AD patients is anticipated to increase dramatically. 2

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