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Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase

✍ Scribed by Brühlmann, Corinne; Ooms, Frédéric; Carrupt, Pierre-Alain; Testa, Bernard; Catto, Marco; Leonetti, Francesco; Altomare, Cosimo; Carotti, Angelo

Book ID
120340794
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
48 KB
Volume
44
Category
Article
ISSN
0022-2623

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A series of irrfino 1,2,3,4-tetrahydrocyclopent [b]indole caltmn~tes was prepared and evaluated as dual acetyichollm, stem~ (ACHE) and monoan-fine oxida~ (MAO) inhibitors. Halogen substitution ortho to the cartmn-me functionality in the eight position resulted in a significant increase in binding af