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Imidazolidin-4-one Derivatives of Primaquine as Novel Transmission-Blocking Antimalarials

✍ Scribed by Araújo, Maria João; Bom, Joana; Capela, Rita; Casimiro, Catarina; Chambel, Paula; Gomes, Paula; Iley, Jim; Lopes, Francisca; Morais, José; Moreira, Rui; de Oliveira, Eliandre; do Rosário, Virgílio; Vale, Nuno


Book ID
120588371
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
75 KB
Volume
48
Category
Article
ISSN
0022-2623

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The synthesis of substituted (4S)-4-(hyd
✍ Lianyun Zhao; Lixin Qiao; Suo-Bao Rong; Alan P Kozikowski 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 133 KB

The total synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium(IV) isopropoxide and sodium cyanoborohydride, followed by the cyclization to ure